After being stigmatized for decades, psychedelic medications are making a comeback on the world stage as the most promising new mental health treatments in the past 50 years. Research indicates psychedelic-assisted therapy may help promote emotional well-being by triggering a variety of experiences, providing people with an enhanced sense of meaning and purpose in their lives. This episode follows a participant in a clinical trial studying the use of psychedelics to alleviate mental suffering and depression. Leading researchers and clinicians discuss the latest scientific breakthroughs and the challenges in bringing this innovative therapy to a wider audience.