After splitting from her boyfriend, junior doctor Ruby Walker seeks a new start away from England and answers an advert to work at the busy, underfunded Good Karma hospital in India, run by straight-talking Doctor Lydia Fonseca, along with elderly surgeon Ram Nair and arrogant younger Gabriel Varna. Ruby wins her spurs dealing with a difficult pregnancy but is overwhelmed by the volume of patients, including Maggie Smart, who is in the country with husband Paul for their daughter's wedding and has a brain tumour. When the team fails to save two brothers brought in suffering from stab wounds Ruby considers quitting but is dissuaded by Lydia--who is not amused to find that her occasional boyfriend Greg McConnell has donated an ambulance advertising his bar